Osteosarcoma

Overview

Osteosarcoma is a type of bone cancer that most commonly occurs in the long bones, such as the arms and legs, but can also develop in other bones. It primarily affects adolescents and young adults, typically between the ages of 10 and 20. Osteosarcoma arises from osteoblasts, which are cells responsible for bone formation.

Common signs and symptoms

  • Pain and swelling in the affected area, which may worsen at night
  • Cough and Shortness of breath if spread to lung
  • Unexplained fractures

Diagnostic tests and procedures

  • Medical History and Physical Exam.
  • Imaging like X-rays, MRI (Magnetic Resonance Imaging), CT (Computed Tomography) Scans and PET (Positron Emission Tomography) Scans.
  • Biopsy to get a small tissue sample from the tumor to confirm cancer cells under a microscope.
  • Blood tests and scans to check for cancer spread (often to the lungs).

Treatment options

Chemotherapy

To shrink the tumor and destroy cancer cells in the body.

Surgery

To remove the tumor aiming to save the affected limb whenever possible.

Radiation therapy

Generally not effective for osteosarcoma but may be used in certain cases where surgery is not possible.

More chemotherapy after surgery to kill any remaining cancer cells.

Prognosis

The prognosis for patients with osteosarcoma depends on several factors, including the tumor’s size, location, presence of metastasis (spread), and response to treatment. When diagnosed early and treated aggressively, many patients can achieve long-term remission.

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