Chronic Myelogenous Leukemia (CML)
Overview
Chronic Myelologenous Leukemia (CML) is a type of blood cancer that begins in the bone marrow, where it causes the body to produce too many abnormal white blood cells called granulocytes.
What causes CML
Most people with CML have a genetic change called the Philadelphia chromosome. This change creates a new gene called BCR-ABL, which makes the cells grow uncontrollably. This gene is not inherited from parents but happens during a person’s life. The exact cause of this change is unknown.
Common signs and symptoms
- Persistent fatigue
- Unexplained fevers
- Night sweats
- Easy bruising or bleeding
- Bone or joint pain
- Swollen lymph nodes, liver and spleen
- Pallor
Diagnostic tests and procedures
- Complete blood count (CBC) can reveal abnormalities in blood cell levels indicative of leukemia.
- Peripheral blood smear to look for abnormal cells.
- Bone marrow aspiration and biopsy to check for cancerous cells .
- Further tests like flow cytometry and genetic tests to predict prognosis and choose the best treatment.
- Imaging like X-rays or CT scans
The Journey of Healing Starts Here
If you or your loved one is experiencing symptoms of Chronic Myelogenous Leukemia, our expert hematology team is here to help. We provide comprehensive diagnostic services, individualized treatment plans, and ongoing support to ensure the best outcomes.
Treatment options
Targeted therapy
These drugs block the abnormal signals that make leukemia cells grow
Chemotherapy
While targeted therapy is the primary treatment, chemotherapy may be used alongside it to manage symptoms.
Bone marrow transplant (BMT)
If targeted therapies and chemotherapy are insufficient, a stem cell transplant may be recommended replace diseased bone marrow with healthy stem cells from a donor.
Supportive care
including blood transfusions, antibiotics for infections, and other medications.
Prognosis
The prognosis for patients with CML has improved significantly over the years due to advancements in treatment options, particularly with targeted therapy. Many patients can achieve long-term remission and maintain a good quality of life.